Firefighters, police and paramedics raced to the blaze in Ewart Drive at around 3:05am.
A huge house fire in Airdrie saw nearby homes evacuated in the early hours of Saturday morning.
The occupants of eight nearby properties were evacuated at the time as a precaution, however, four have since been allowed to return.
The others remain with family and friends.
It is not known at this stage whether anyone has been injured.
A spokeswoman for Police Scotland said: “Police and emergency services were called to a report of a fire within a detached house in Ewart Drive, Airdrie.